IUI Treatment

What is IUI?

Intrauterine insemination or IUI treatment is the placing of sperm into a woman's uterus during ovulation. This procedure is used for couples with unexplained infertility, minimal factor of male infertility, and women with cervical mucus problems. IUI treatment is often done in along with ovulation-stimulating drugs. Intrauterine insemination can be performed by using the husband's sperm or donor sperm. Before Intrauterine insemination, the woman should be evaluated for any hormonal imbalance, infection or any structural problems.

IUI may be used in along with ovulatory medications, such as clomiphene citrate, gonadotropins, or urofollitropin. If injectable ovulation Stimulating drugs are used in an IUI cycle, careful monitoring is essential. Monitoring includes periodic blood tests and ultrasounds beginning around day 6 of the woman's cycle. Results of these tests will indicate when eggs are mature, prompting the HCG shot.

Intrauterine insemination IUI treatment is also used with specially prepared donor sperm. The sperm bank sends the doctor's office sperm that is already prepared. Intrauterine insemination is a relatively quick procedure and is performed in the doctor's office without any anesthesia. It should not be painful, although some women report mild discomfort.

What to Expect Post-Procedure of IUI Treatment

  • After the IUI procedure, you may be prescribed progesterone. This is usually taken via a vaginal suppository and oral drugs .
  • About a week after the IUI, one's doctor may order blood work. He will check one's progesterone levels, estrogen, and (perhaps) hCG levels.
  • 10 to 14 days post-IUI, one's doctor may order a pregnancy blood test. Or, he may, in fact, suggest a home test.

Success Rate of IUI Treatment

In cycles wherever fertility drugs and IUI were combined, the pregnancy rate was 8 percent to 15 percent. These are per cycle rates, meaning that the success odds are higher when looking at multiple cycles together.

One's personal success rate will indeed very much be depending on the cause of one's infertility and one's age.

INDICATIONS OF IUI TREATMENT

This is a basic fertility treatment indicated in couples with:

  • The permeability of the fallopian tubes is a prerequisite for this treatment.
  • Limit sperm count
  • Sperm motility parameters decreased
  • Ejaculatory dysfunction
  • Donor sperm
  • Unexplained infertility
  • Induction of ovulation with gonadotropins

What Are The Prerequisites For IUI Treatment?

  • Atleast one tube which is open / patent
  • Ovulation by ultrasound scan
  • Good sperm count / motility
  • Good endometrial lining

Sperm DNA Fragmentation Introduction

  • Almost 50% of all cases of infertility may be associated with a male factor. A semen analysis that measures sperm concentration, motility and morphology has classically been used as the gold standard test for determining a man's fertility. However, this test does not provide any information about the genetic constitution of the sperm, which is essential for normal embryo development. Thus a high level of DNA damage in sperm cells may represent a cause of male infertility that conventional examinations cannot detect. 

Causes of Sperm DNA Fragmentation

  • Infection
  • Pyrexia
  • Elevated testicular temperature
  • Recreational drugs use
  • Smoking
  • Alcohol
  • Stress
  • Diet
  • Environmental and occupational pollutants
  • Advanced age
  • Varicocoele
  • Leucocytospermia
  • Sperm cytoplasmic droplets

Indications for Male Patients

Who May Benefit from a Sperm   DNA Fragmentation Test

  • Unexplained Infertility
  • Arrested Embryo Development
  • Poor Blastocyst Development
  • Multiple Failed IVF/ICSI treatment
  • Recurrent miscarriage in partner
  • Advanced age
  • Varicocoele
  • Poor semen parameters
  • Exposure to harmful substances

DFI methods

  • HALO METHOD
  • TUNNEL ASSAY FLOW CYTOMETRY
  • FISH (Fluorescent In Situ Hybridisation)